Asian Journal of Research in Chemistry

Milan Hait ¹, Shivi Sharma ²

Affiliations
1 Dept. of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G. 495113
2 Dept. of Chemistry, Govt. College Bishrampur, Surguja District, C.G

Abstract

The present investigation has been focused in Bishrampur and Bhadgao regions of Surguja Coal field area since these are major coal mining areas of Surguja district which are prone for ecological imbalance. The sampling method was based on primary and secondary data collection during the research study in three areas namely Coal mining area, Forest area, and Urban area. The water samples were collected in the month of November'2010 from hand pumps, tube wells and ponds, were considered under primary data collection technique and its Temperature, p<SUP>H</SUP>, E.C, T.S, TDS, TSS, Alkalinity, TH, D.O, BOD, COD, F<SUP>−</SUP>, Cl<SUP>−</SUP>, SO<SUB>4</SUB> <SUP>2−</SUP>, NO<SUP>3 −</SUP> etc. Were determined using p<SUP>H</SUP> meter, titration, water analyzer and spectrophotometer etc. It was found that deteriorating water quality due to mining, continued to ruin the health standards of local people, reduced the number of flora and fauna, reduced the agricultural land area and it constrained farmers to migrate, this led to increased entropy in ecology of Bishrampur and Bhadgao regions causing an ecological imbalance.

Keywords

Physico-chemical Parameters, Water Analysis And Ecological Imbalance

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Milan Hait ¹, Kavita Nag ¹, Shivi Sharma ¹, Sangeeta Sharma ², Leena Sahu ³

Affiliations
1 Dept. of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495, IN
2 Dept. of Biotechnology, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495113, IN
3 Dept. of Pharmacy, Columbia Institute of Pharmacy, Tekari, Raipur, C.G., IN

Abstract

Analytical studies of some selected physicochemical parameter were made on the surface and underground water bodies at Siltara industrial area, Raipur. Siltara industrial area is situated 5 km away from the Raipur city, Chhattisgarh. Both surface and underground water samples were collected in the month of October'2010. Temperature, P^H, E.C, Salinity, TDS, D.O etc. were analyzed instantly on the sampling spots while T.S, TSS, TH, Alkalinity, D.O, BOD, COD, Cl⁻, SO₄²⁻, NO₃⁻, Fe etc. were analyzed in the laboratory of pollution Control Board, Bilaspur, C.G. It was observed that Temperature, P^H, Alkalinity, TH, DO, BOD, Cl⁻, SO₄²⁻, NO₃⁻ and Fe have higher value than maximum permissible limit of IS: 10500. The elevated values of these parameters are of great concern to public health when the water from these well, bore well and hand pump are consumed by people without treatment. Commercial effluents polluted both surface and underground water bodies.

Keywords

Physiochemical Property, Commercial Effluent, Surface Water, Underground Water.

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Dibyajyoti Saha ¹, Milan Hait ²

Affiliations
1 School of Pharmacy, Chouksey Engineering College, Lal Khadan, Masturi Road, Bilaspur, C.G.-495004, IN
2 Depatment of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495004, IN

Abstract

Lead optimization employs a combination of empirical, combinatorial and rational approaches that optimize leads through continuous, multi speed process based on knowledge gained at each stage. The testing of analog series result in quantitative information that correlates changes in chemical structure to biological and pharmacological data generate to established SARs. The medicinal chemistry- lead optimization blends synthetic chemistry, molecular modeling, computational biology, structural genomics and pharmacology to discover and design new drugs and investigate their interaction at the molecular, cellular and whole animal level. The present pathways give mechanism of animal PK/PD/ADMEs highlighting the toxicity, formulation and delivery.

Keywords

Lead Optimization, Medicinal Chemistry.

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Milan Hait ¹, Ashutosh Patel ¹, Champa Singh Rajput ¹

Affiliations
1 Dept. of Chemistry, Dr. C.V. Raman University, Kargi Road, Kota, Bilaspur, C.G.-495113, IN

Abstract

The heavy metal levels as micronutrients like Iron (Fe), copper (Cu) and Zinc (Zn) were determined using Digital spectrometer in three different samples of leafy vegetables, purchased from Dharmjaygarh market in Raigarh district of Chhattisgarh. The maximum concentration of Fe, Cu and Zn were found 22.14 mg/kg, 0.72 mg/kg and 6.3 mg/kg in Palak Bhaji, Lal Bhaji and Palak Bhaji respectively. The minimum concentration of Fe, Cu and Zn were found 6.23 mg/kg, 0.21 mg/kg and 1.52 mg/kg. The relative abundance of metals in leafy vegetables followed the sequence Cu (0.52 mg/kg) < Zn (4.33 mg/kg) < Fe (15.58 mg/kg). The levels of Fe, Cu and Zn were below the FAO/WHO recommended limits for metals in vegetables. Low concentrations of Cu, Fe and Zn in all the samples are indications that these plants contribute no toxic effects of metals. The results showed that, these vegetables are the main sources of essential trace elements. The daily human intakes of metals have also been calculated which were observed below recommended values by the FAO/WHO.

Keywords

Heavy Metals, Micronutrients, Leafy Vegetable, Local Market, Analysis and Public Health.

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